淀粉樣蛋白β1-42(Ab1-42)單克隆抗體
Monoclonal Antibody to Amyloid Beta Peptide 1-42 (Ab1-42)
- 編號MAA946Ge21
- 物種Pan-species (General，通用) 相同的名稱，不同的物種。
- 來源單抗制備
- 宿主小鼠
- 效價(克隆號)C4
- Ig亞型 IgG2b Kappa
- 純化方式蛋白A + 蛋白G親和純化
- 標記物無標記物
- 免疫原 -
- 緩沖液成份磷酸鹽緩沖液（pH7.4,含有0.02% NaN3和50%甘油）
- 性狀液體
- 濃度1mg/ml
- 且適物種Pan-species (General，通用)
- 應(yīng)用WB; IHC; ICC; IP.
如果抗體需用于流式細胞術(shù)，請參見流式抗體。 - 下載 英文說明書 中文說明書
- 規(guī)格 20μl100μl 200μl 1ml 10ml
- 價格 ¥ 716 ¥ 1672 ¥ 2388 ¥ 5970 ¥ 23880
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產(chǎn)品包裝(模擬)
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產(chǎn)品包裝(模擬)
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DAB staining on IHC-P; Samples: Human Cerebrum Tissue; Primary Ab: 30μg/ml Mouse Anti-Human Ab1-42 Antibody Second Ab: 2μg/mL?HRP-Linked Caprine Anti-Mouse IgG Polyclonal Antibody (Catalog: SAA544Mu19)
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IHC圖
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IHC圖
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IHC圖
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IHC圖
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IHC圖
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Western Blot; Sample: Human Hela cell lysate.
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Western Blot; Sample: Human 293T cell lysate;
Primary Ab: 5μg/ml Mouse Anti-Multi-species Ab1-42 Antibody
Second Ab: 0.2μg/mL?HRP-Linked Caprine Anti-Mouse IgG Polyclonal Antibody
(Catalog: SAA544Mu19)
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通過ISO 9001、ISO 13485質(zhì)量體系認證
特異性
該抗體是針對Ab1-42的小鼠單克隆抗體。在免疫組織化學(xué)染色和免疫印跡實驗中能識別Ab1-42。
用法
Western blotting: 0.01-5μg/mL;
Immunohistochemistry: 5-30μg/mL;
Immunocytochemistry: 5-30μg/mL;
Optimal working dilutions must be determined by end user.
儲存
經(jīng)常使用則4°C保存。-20°C保存不超過兩年。避免反復(fù)凍融。
穩(wěn)定性
熱穩(wěn)定性以損失率顯示。損失率是由加速降解試驗決定，具體方法如下：在37°C孵育48小時，沒有顯著的降解或者沉淀產(chǎn)生。保質(zhì)期內(nèi)，在適當(dāng)?shù)臈l件下存儲，損失率低于5%。
贈品
增值服務(wù)
相關(guān)產(chǎn)品
| 編號 | 適用物種：Pan-species (General，通用) | 應(yīng)用(僅供研究使用，不用于臨床診斷！) |
| CPA946Ge21 | 淀粉樣蛋白β1-42(Ab1-42)卵白蛋白偶聯(lián)物 | Immunogen; SDS-PAGE; WB. |
| MAA946Ge28 | 淀粉樣蛋白β1-42(Ab1-42)單克隆抗體 | WB; IHC; ICC; IP. |
| MAA946Ge21 | 淀粉樣蛋白β1-42(Ab1-42)單克隆抗體 | WB; IHC; ICC; IP. |
參考文獻
| 雜志 | 參考文獻 |
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| Neuropharmacology and analgesia | The γ-secretase inhibitor 2-[(1R)-1-[(4-chlorophenyl)sulfonyl](2,5-difluorophenyl) amino]ethyl-5-fluorobenzenebutanoic acid (BMS-299897) alleviates Aβ1–42 seeding and short-term memory deficits in the Aβ25–35 mouse model of Alzheimer's disease [Pubmed: 23123349] |
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| 世界科技研究與發(fā)展 | 芝麻素對高糖條件下PC12 細胞A? 和BACE 1 表達的影響?yīng)?[QK:92621A] |
| Archives of Pharmacal Research | Geniposide attenuates the level of Aβ1–42?via enhancing leptin signaling in cellular and APP/PS1 transgenic mice [pubmed:28160136] |
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| Scientific Reports | Norovirus P particle-based active Aβ immunotherapy elicits sufficient immunogenicity and improves cognitive capacity in a mouse model of Alzheimer’s disease [articles:srep41041.ris] |
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| Journal of Affective Disorders | Sub-chronic celecoxib prevents soluble beta amyloid-induced depressive-like behaviour in rats [Pubmed:29879605] |
| Biomedicine & Pharmacotherapy | Punicalagin ameliorates the elevation of plasma homocysteine, amyloid-β, TNF-α and apoptosis by advocating antioxidants and modulating apoptotic mediator proteins in brain modulating apoptotic mediator?… [Pubmed:29579708] |
| Journal of Agricultural and?Food?Chemistry | Effects of Astaxanthin and Docosahexaenoic-Acid-Acylated Astaxanthin on Alzheimer's Disease in APP/PS1 Double-Transgenic Mice [Pubmed:29695154] |
| Neurotoxicology | Amelioration by nitric oxide (NO) mimetics on neurobehavioral and biochemical changes in experimental model of Alzheimer's disease in rats [Pubmed:29522778] |
| Biochemical and Biophysical?Research?Communications | CART peptide activates the Nrf2/HO-1 antioxidant pathway and protects hippocampal neurons in a rat model of Alzheimer's disease [Pubmed:29777699] |
| Oncotarget | Deletion of plasma Phospholipid Transfer Protein (PLTP) increases microglial phagocytosis and reduces cerebral amyloid-β deposition in the J20 mouse?… [Pubmed:29731975] |
| Experimental?and?Therapeutic?Medicine | Ellagic acid ameliorates learning and memory impairment in APP/PS1 transgenic mice via inhibition of β?amyloid production and tau hyperphosphorylation [Doi: 10.3892/etm.2018.6860] |
| 非編碼RNA miR-137 調(diào)控tau 蛋白磷酸化和L 型鈣離子通道CACNA1C 參與阿爾茨海默病的發(fā)生 [] | |
| 臺灣農(nóng)業(yè)研究 | (臺灣農(nóng)業(yè)研究67 (4): 355-364) 香菇柄水萃物改善糖尿病降低阿茲海默氏癥罹病風(fēng)險初探 [] |
| The Efficacy of Sauropus androgynus Leaves Extract To Improve Cognitive Function in Wistar Rats Induced Alzheimer's [] | |
| Neurotoxicity Research | Effect of Aluminum-Maltolate on the Content of Aβ Protein and the Expression of ApoER2, VLDLRs, and LRP1 in PC12-ApoE4 Cells [Pubmed: 30649678] |
| Neurochemical?Research | Imbalance of Microglial TLR4/TREM2 in LPS-Treated APP/PS1 Transgenic Mice: A Potential Link Between Alzheimer's Disease and Systemic Inflammation [Pubmed: 30756214] |
| Molecular and Cellular Biochemistry | Repetitive transcranial magnetic stimulation protects mice against 6-OHDA-induced Parkinson's disease symptoms by regulating brain amyloid β level [] |
| PLoS One | Obstructive sleep apnea may increase the risk of Alzheimer's disease [Pubmed: 31487291] |
| Metabolic Brain Disease | Nanoformulated ellagic acid ameliorates pentylenetetrazol-induced experimental epileptic seizures by modulating oxidative stress, inflammatory cytokines and?… [Pubmed: 31728888] |
| 博士論文 | Neurobiological determinants of depressive-like symptoms in rodents [] |
| Pharmacognosy Magazine | Mahanimbine-induced neuroprotection via cholinergic system and attenuated amyloidogenesis as well as neuroinflammation in lipopolysaccharides-induced?… [] |
| biosciences biotechnology research asia | Dietary Malted Barley Grain Improved Structure and Function of Spinal Cord of Mother Rats fed on a high cholesterol diet. [] |
| Neurochem Res | Ex Vivo Investigation of Bexarotene and Nicotinamide Function as a Protect?ve Agent on Rat Synaptosomes Treated with A|? (1-42) [33428094] |
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| Int J Neurosci | Protective effects of repetitive transcranial magnetic stimulation against 6-OHDA-induced Parkinson's symptoms in a mice model: the key role of miR-409-3p/PDHB ?- [34078216] |
| Brain Res Bul | Immunization with A|?3-10-KLH vaccine improves cognitive function and ameliorates mitochondrial dysfunction and reduces Alzheimer's disease-like pathology in Tg ?- [34044034] |
| PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS | The effect of a 6-month Ketogenic Medium-Chain Triglyceride Supplement on Plasma Cardiometabolic and Inflammatory Markers in Mild Cognitive??- [33906081] |
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